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  • Title: "Applause sign" helps to discriminate PSP from FTD and PD.
    Author: Dubois B, Slachevsky A, Pillon B, Beato R, Villalponda JM, Litvan I.
    Journal: Neurology; 2005 Jun 28; 64(12):2132-3. PubMed ID: 15985587.
    Abstract:
    The "applause sign" is a simple test of motor control that helps to differentiate PSP from frontal or striatofrontal degenerative diseases. It was found in 0/39 controls, 0 of 24 patients with frontotemporal dementia (FTD), 0 of 17 patients with Parkinson disease (PD), and 30/42 patients with progressive supranuclear palsy (PSP). It discriminated PSP from FTD (p < 0.001) and PD (p < 0.00). The "three clap test" correctly identified 81.8% of the patients in the comparison PSP and FTD and 75% of the patients in the comparison of PSP and PD.
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