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  • Title: Effect of LH on prostaglandin F2alpha and prostaglandin E2 secretion by cultured porcine endometrial cells.
    Author: Blitek A, Ziecik AJ.
    Journal: Reproduction; 2005 Jul; 130(1):105-12. PubMed ID: 15985636.
    Abstract:
    LH appears to be a potent stimulator of the release of endometrial prostaglandins (PGs) in the pig. The aim of the present studies was to examine the effect of LH on PGF2alpha and PGE2 secretion by cultured porcine endometrial cells on days 10-12 and 14-16 of the oestrous cycle and to compare its action with oxytocin. A time-dependent effect of LH (10 ng/ml) on PGF2alpha release from luminal epithelial and stromal cells on days 10-12 was observed (experiment 1). The highest increase in PGF2alpha secretion in response to LH was detected in stromal cells after 6 h of incubation (P < 0.001). Epithelial cells responded to LH after a longer exposure time (P < 0.01). A concentration-dependent effect of LH (0.1-100 ng/ml) on PGF2alpha release from stromal cells was examined after 6 h and from epithelial cells after 12 h (experiment 2). Effective concentrations of LH were 10 and 100 ng/ml. LH (10 ng/ml) and oxytocin (100 nmol/l) affected PGF2alpha and PGE2 secretion from endometrial cells on days 10-12 and 14-16 of the oestrous cycle (experiment 3). LH stimulated PGF2alpha secretion from both cell types and its action was more potent on days 10-12. LH induced PGE2 release, especially in epithelial cells on days 14-16. A stimulatory effect of oxytocin on PGF2alpha was confirmed in stromal cells, but this hormone was also shown to enhance PGE2 output. These results indicated that LH, like oxytocin, a very effective stimulator of PGF2alpha release, could play an important role in the induction of luteolysis.
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