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  • Title: Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex.
    Author: Liauw J, Wu LJ, Zhuo M.
    Journal: J Neurophysiol; 2005 Jul; 94(1):878-82. PubMed ID: 15985698.
    Abstract:
    Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.
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