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  • Title: [Effect of carbon tetrachloride intoxication on leakage of intracellular potassium in regenerating rat hepatocytes in vitro].
    Author: Zhang BH, Mei MH.
    Journal: Sheng Li Xue Bao; 1992 Feb; 44(1):62-8. PubMed ID: 1598595.
    Abstract:
    Leakage of intracellular potassium and GPT in normal rat hepatocytes exposed to 10, 15 and 20 mmol/L of carbon tetrachloride (CCl4) in vitro was determined at 5, 10, 15 and 20 min after cell intoxication. Both of the intracellular potassium and GPT were clearly dose- and time-dependent with CCl4, but the leakage of intracellular potassium is a more sensitive index to indicate cell injury than the later. The percent change of intracellular potassium in regenerating rat hepatocytes 20 min after CCl4 (15 mmol/L) intoxication was markedly reduced than that in normal rat. This finding indicates that regenerating hepatocytes are resistant to CCl4 hepatotoxicity in vitro, and its mechanism presumably is due to a higher stability of regenerating liver cell membrane.
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