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  • Title: Thymoma and hypogammaglobulinemia (Good's syndrome): a case report.
    Author: Tsai YG, Lai JH, Kuo SY, Chen HC, Chang DM.
    Journal: J Microbiol Immunol Infect; 2005 Jun; 38(3):218-20. PubMed ID: 15986073.
    Abstract:
    Good's syndrome is extremely rare and refers to an acquired B and T cell immunodeficiency in thymoma patients. We report a 51-year-old female thymoma patient who presented with recurrent herpes zoster, pneumonia, diarrhea and opportunistic infections. She was found to have acquired hypogammaglobulinemia with absent B cells. Despite repeat intravenous immunoglobulin replacement and antibiotic therapy, she died of bacterial pneumonia-induced acute respiratory distress syndrome. Clinicians should look for evidence of immunologic dysfunction in thymoma patients presenting with recurrent infections.
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