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  • Title: [Structural and metabolic characteristics of erythrocytes in patients with systemic vasculitis].
    Author: Fazlyev MM, Gil'manov AZh.
    Journal: Klin Lab Diagn; 2005 May; (5):34-7. PubMed ID: 15986796.
    Abstract:
    We studied the functional and metabolic changes of erythrocytes in systemic vasculitis (SV). The below was detected: an increasing intensity of blood chemiluminescence, a higher concentration of TBA-positive substances in erythrocyte membranes, inhibited Na+, K+ - and Ca2+ -activated and Mg2+ -related ATPases in erythrocytes and a reduced osmotic and acidic resistance of erythrocytes. An enhanced aggregation ability of erythrocytes and their inhibited desagregation were observed in hemorrhagic vasculitis an especially in microscopic polyangiitis. The revealed changes characterize the significance of the erythrocyte pathology in thrombosis and development of hemorrhagic disorders in SV patients.
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