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  • Title: Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z.
    Author: Ghalit N, Poot AJ, Fürstner A, Rijkers DT, Liskamp RM.
    Journal: Org Lett; 2005 Jul 07; 7(14):2961-4. PubMed ID: 15987180.
    Abstract:
    [reaction: see text] Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4-7 amino acid residues in yields ranging from 18 to 82%.
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