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  • Title: [Identification of proteins interacting with adaptor protein Bam32].
    Author: Cheng XX, Jian R.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2005 Jul; 21(4):432-4. PubMed ID: 15989784.
    Abstract:
    AIM: To study the role of adaptor protein Bam32 in B cell antigen receptor (BCR) signaling cascades. METHODS: Using full length Bam32 as bait, yeast two-hybrid technique was used to screen the protein that could interact with Bam32. The interaction was further confirmed by co-transfection of 293T cells and coimmunoprecipitation. RESULTS: Protein tyrosine kinase Lyn was one of the strong positive clones identified by the yeast two-hybrid screening. This interaction was further confirmed in 293T cells by co-transfection and coimmunoprecipitation. By using specific anti-phosphotyrosine antibody, it was found that Bam32 could be phosphorylated by Lyn. CONCLUSION: The interaction of Bam32 with Lyn leads to Bam32 phosphorylation, which might play an important role in activating downstream signaling molecules.
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