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  • Title: A facile synthesis of [(11)C]acetylene.
    Author: Nazih R, Blauser JP, Mock BH, Degrado TR.
    Journal: Appl Radiat Isot; 2005 Sep; 63(3):305-9. PubMed ID: 15990324.
    Abstract:
    Acetylene is a versatile synthon organic chemistry. The complexity and difficulty of synthesis of [(11)C]acetylene has limited its use as a labeling intermediate for PET radiotracers. A new method for production of [(11)C]acetylene has been developed in our laboratory that simplifies the synthesis procedure allowing for easy automation and implementation. The technique is a modification of Madsen et al. (1981, Phys. Med. Biol. 26(5), 875) that utilized carbon dioxide ((11)C) and barium. First [(11/12)C]CO(2) was trapped at room temperature on barium within a quartz reaction tube, then heated to 900 degrees C under hydrogen flow to release [(11)C]acetylene. Hydrogen gas is apparently oxidized to form water vapor which reacts immediately with the formed carbide to liberate acetylene. Radiochemical yields of 31.4--75.4% and specific activities of 0.11-- 161 mCi/micromol have been obtained with radiochemical purities greater than 99%. This technique provides a new, efficient and very practical synthesis of [(11)C]acetylene that can be utilized as synthon for novel PET radiopharmaceuticals.
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