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  • Title: Serotonergic pathways converge upon central melanocortin systems to regulate energy balance.
    Author: Zhou L, Williams T, Lachey JL, Kishi T, Cowley MA, Heisler LK.
    Journal: Peptides; 2005 Oct; 26(10):1728-32. PubMed ID: 15993514.
    Abstract:
    Multiple lines of research provide compelling support for an important role for central serotonergic (5-hydroxytryptamine, 5-HT) and melanocortin pathways in the regulation of food intake and body weight. In this brief review, we outline data supporting a model in which serotonergic pathways affect energy balance, in part, by converging upon central melanocortin systems to stimulate the release of the endogenous melanocortin agonist, alpha-melanocyte stimulating hormone (alpha-MSH). Further, we review the neuroanatomical mapping of a downstream target of alpha-MSH, the melanocortin 4 receptor (MC4R), in the rodent brain. We propose that downstream activation of MC4R-expressing neurons substantially contributes to serotonin's effects on energy homeostasis.
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