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  • Title: [Mechanisms of action in bisphosphonates].
    Author: Hoshino H, Yamazaki K.
    Journal: Clin Calcium; 2005 Jul; 15(7):88-92. PubMed ID: 15995302.
    Abstract:
    Bisphosphonates have the high affinity to hydroxyapatites and act as the inhibition of bone resorption in a low dose, while they act as the inhibition of the calcification in a high dose. In tissues, bisphosphonates adsorbing bone surface become detached by a low pH environment with bone resorption and then act on osteoclasts. In cellular events, nitrogen-containing compounds interfere with protein prenylation by inhibiting an enzyme in the HMG-CoA reductase pathway. On the other hand, non-nitrogen-containing bisphosphonates act by producing toxic analogs of ATP that cause cell death.
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