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  • Title: Prevention of chromate induced oxidative stress by alpha-lipoic acid.
    Author: Budhwar R, Kumar S.
    Journal: Indian J Exp Biol; 2005 Jun; 43(6):531-5. PubMed ID: 15997482.
    Abstract:
    The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
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