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  • Title: Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives.
    Author: Kaffy J, Pontikis R, Florent JC, Monneret C.
    Journal: Org Biomol Chem; 2005 Jul 21; 3(14):2657-60. PubMed ID: 15999202.
    Abstract:
    Stereospecific syntheses of the Z-E and E-Z vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki-Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its ability to inhibit tubulin polymerisation.
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