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  • Title: A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population.
    Author: Macciardi F, Kennedy JL, Ruocco L, Giuffra L, Carrera P, Marino C, Rinaldi V, Smeraldi E, Ferrari M.
    Journal: Biol Psychiatry; 1992 Apr 01; 31(7):720-8. PubMed ID: 1599988.
    Abstract:
    Some recent findings report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigrees segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
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