These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Aspects of Bcl-2 proto-oncogene expression in dysplastic and malignant lesions of the uterine cervix].
    Author: Borţun F, Chiovschi S, Moldovan M.
    Journal: Rev Med Chir Soc Med Nat Iasi; 2004; 108(4):821-6. PubMed ID: 16004225.
    Abstract:
    We studied Bcl-2 proto-oncogene expression in dysplastic and malignant lesions of the uterine cervix and looked for a relation between its incidence and tumor histopathologic type and tumor differentiation grade. We used immunohistochemical reaction with a Bcl-2 specific monoclonal antibody in order to identify this protein in 40 patients' biopsies. We noticed a Bcl-2 nuclear immunoreaction in high differentiated squamous carcinomas, whereas a positive cytoplasmic reaction of a granular pattern was registered in low differentiated types. Distribution and intensity of Bcl-2 reaction final product was correlated with tumor differentiation grade in 29 of all studied cases (72.5%). Immunostaining technique may be an important adjuvant factor for a more accurate prognosis.
    [Abstract] [Full Text] [Related] [New Search]