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  • Title: [Influence of trauma-hemorrhagic shock on endotoxin, tumor necrosis factor-alpha and interleukin-6 levels in mesenteric lymph and blood of rats].
    Author: Gu BC, Liu ZJ, Shi HP, Liu LM.
    Journal: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue; 2005 Jul; 17(7):403-5. PubMed ID: 16004777.
    Abstract:
    OBJECTIVE: To investigate the influence of trauma-hemorrhagic shock on endotoxin (ET), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels in mesenteric lymph and blood of rats. METHODS: Mesenteric lymph from trauma-hemorrhagic shock rats were collected, levels of ET, TNF-alpha and IL-6 in mesenteric lymph were compared with those from blood samples. RESULTS: Levels of ET, TNF-alpha and IL-6 in mesenteric lymph were elevated during shock period (all P<0.05), and they were decreased to normal range after resuscitation, with an exception of high IL-6 level up to 2 hours following resuscitation. CONCLUSION: The bacterial translocation could occur during shock period via lymphatic pathway, thereby leading to the increase in TNF-alpha and IL-6 levels, as well as systemic inflammatory response syndrome.
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