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  • Title: Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs.
    Author: Wang YD, Johnson S, Powell D, McGinnis JP, Miranda M, Rabindran SK.
    Journal: Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3763-6. PubMed ID: 16005212.
    Abstract:
    On the basis of a screening lead from an assay using a pair of p21 isogenic cell lines (p21-proficient cells and p21-deficient cells) to identify chemoselective agents, a series of novel thieno[2,3-d]pyrimidin-4(1H)-one-based analogs was prepared. Some analogs inhibited the growth of human colon tumor cells.
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