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  • Title: Gene expression profiling reveals an inflammatory process in the anx/anx mutant mice.
    Author: Lachuer J, Ouyang L, Legras C, Del Rio J, Barlow C.
    Journal: Brain Res Mol Brain Res; 2005 Oct 03; 139(2):372-6. PubMed ID: 16006007.
    Abstract:
    Anorexia (anx) is a recessive mutation that causes lethal starvation in homozygous mice. Studies of anx/anx mice hypothalamus have shown abnormalities in the orexigenic (NPY/AGRP neurons) and the anorexigenic (POMC/CART neurons) pathways. By gene expression profiling using cDNA and oligonucleotide microarrays, we have shown that a surexpression of genes involved in inflammatory process occurred in anx mice hypothalamus. This inflammatory process could be the cause of the anorexia phenotype observed in these mice.
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