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  • Title: In vivo mechanical properties of thoracic aortic aneurysmal wall estimated from in vitro biaxial tensile test.
    Author: Fukui T, Matsumoto T, Tanaka T, Ohashi T, Kumagai K, Akimoto H, Tabayashi K, Sato M.
    Journal: Biomed Mater Eng; 2005; 15(4):295-305. PubMed ID: 16010038.
    Abstract:
    To investigate the mechanism of aneurysm rupture, it is necessary to examine the mechanical properties of aneurysm tissues in vivo. A new approach to evaluate in vivo mechanical properties of aortic aneurysmal tissues has been proposed in this study. The shape of the aneurysm was modeled as a sphere, and equi-biaxial stress in the in vivo state was estimated from the diameter and the wall thickness of each aneurysm and mean blood pressure of each patient. The mechanical properties of the aneurysm at the in vivo stress were estimated from its in vitro biaxial tensile properties. There were no significant correlations among maximum diameter D, wall thickness t, and mean infinitesimal strain in the in vivo state epsilon(m). This indicates the wall deformation during aneurysm development was not elastic but plastic. The mean incremental elastic modulus H(m), an index of tissue stiffness, had a significant positive correlation with elastic modulus anisotropy index K(H). This indicates the aneurysmal wall got more anisotropic in vivo as it becomes stiffer.
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