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  • Title: [The antitumor effects of total-flavonoid from Stellera chamaejasmel].
    Author: Wang M, Jia ZP, Ma J, Wang B.
    Journal: Zhongguo Zhong Yao Za Zhi; 2005 Apr; 30(8):603-6. PubMed ID: 16011286.
    Abstract:
    OBJECTIVE: To study the antitumor effects of total-flavonoid from S. chamaejasmel. METHOD: The in vitro antitumor activity against human cancer cell lines, such as stomach cancer SGC-7901, hepatocarcinoma BEL-7402 and leukemia HL-60, were determined by a MTT and clone formation assay. The in vivo antitumor activity was evaluated by the antitumor bioassay against transplanted mouse solid tumor S180 and H22. RESULT: The total-flavonoid inhibited cell proliferation of human tumor cell lines, and its activities are higher than that of vincristine. The total-flavonoid also showed a lower acute toxicity and the strong antitumor activity against transplanted mouse solid tumor S180 and H22 in vivo showing a positive correlation with the concentration. The inhibitory rates at the dose of 0.10 g x kg(-1) ip against S180 and H22 are 45.64% and 47.59%, respectively. CONCLUSION: The total-flavonoid from S. chamaejasme has antitumor activities in vivo and in vitro.
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