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  • Title: Protease inhibitor (Pi) locus, fertility and twinning.
    Author: Boomsma DI, Frants RR, Bank RA, Martin NG.
    Journal: Hum Genet; 1992 May; 89(3):329-32. PubMed ID: 1601424.
    Abstract:
    In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen.
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