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  • Title: [Fibrinogen substitution. Use in the treatment of bleeding due to lack of fibrinogen].
    Author: Ingerslev J, Sørensen B.
    Journal: Ugeskr Laeger; 2005 Jun 20; 167(25-31):2759-61. PubMed ID: 16014260.
    Abstract:
    Fibrinogen is critically important in haemostasis. The concentration of fibrinogen in plasma is usually between 2 and 4 g/l (6-13 micromol/l). No detectable fibrinogen is found in afibrinogenaemia, a condition characterised by dramatic bleeding, while dys- and hypofibrinogenaemia have a lower-than-normal activity of functional fibrinogen. Acquired fibrinogen deficiency may occur with a variety of underlying pathologies. Fibrinogen substitution may be done with fresh-frozen plasma, cryoprecipitate and virally inactivated concentrates of fibrinogen.
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