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  • Title: [Long-term treatment of bradycardia by means of an atropine ester (SCH 1000). Electrophysiological and clinical results].
    Author: Trieb G, Mertens HM, Bistreanu I, Mannebach H, Gleichmann U.
    Journal: Z Kardiol; 1979 Oct; 68(10):700-4. PubMed ID: 160146.
    Abstract:
    Electrophysiological effects of the atropin ester Ipatropiumbromide (SCH 1000) were investigated in 15 patients by His electrocardiography and high frequency atrial stimulation. Heart rate increased by 50% of base line heart rate, PA- and AH-intervals and sinus node recovery time decreased, the HF-interval remained unchanged. Physiological av-block by atrial stimulation occurred at significant higher stimulation frequencies with SCH 1000 than without medication. Additional 15 patients were treated for a longer follow-up period. Increase of resting heart rate averaged 15%. Equivocal effects on heart rate were found with exercise after SCH 1000. Non-cardiac side effects were found in 5 patients.
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