These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Concise syntheses of (+)-macrosphelides A and B.
    Author: Paek SM, Seo SY, Kim SH, Jung JW, Lee YS, Jung JK, Suh YG.
    Journal: Org Lett; 2005 Jul 21; 7(15):3159-62. PubMed ID: 16018610.
    Abstract:
    [reaction: see text]. Unified and highly convergent total syntheses of (+)-macrosphelides A and B are described. Key features of the syntheses include (1) concise synthesis of the optically active delta-hydroxy-gamma-keto alpha,beta-unsaturated acid fragment via the direct addition of a trans-vinylogous ester anion equivalent to the readily available Weinreb amide and (2) facile construction of the 16-membered macrolide core of the macrosphelide series via an intramolecular nitrile-oxide cycloaddition (INOC).
    [Abstract] [Full Text] [Related] [New Search]