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  • Title: Total synthesis of the neotropical poison-frog alkaloid (-)-205B.
    Author: Smith AB, Kim DS.
    Journal: Org Lett; 2005 Jul 21; 7(15):3247-50. PubMed ID: 16018632.
    Abstract:
    [reaction: see text]. A stereocontrolled total synthesis of the neotropical poison-frog alkaloid (-)-205B (1) has been achieved, employing a dithiane three-component linchpin coupling, a one-pot sequential construction of the embedded indolizidine ring, and ring-closing metathesis (RCM) to arrive at the novel 8b-azaacenaphthylene ring system comprising the alkaloid. The synthesis proceeded with a longest linear sequence of 19 steps, affording (-)-1 in 5.6% overall yield.
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