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  • Title: A two-stage iterative process for the synthesis of poly-oxazoles.
    Author: Atkins JM, Vedejs E.
    Journal: Org Lett; 2005 Jul 21; 7(15):3351-4. PubMed ID: 16018658.
    Abstract:
    [reaction: see text]. Methodology has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C(2)-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C(2)-C(4)(') bond by S(N)Ar substitution with TosMIC anion, followed by conversion to the heterocycle in a one-pot reaction with glyoxylic acid monohydrate, affords the desired bis-oxazole in good yield and purity. The two-stage process allows for efficient synthesis of a tris-oxazole and the first iterative preparation of a tetra-oxazole.
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