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  • Title: Electron-capture gas chromatographic procedure for simultaneous determination of amphetamine and N-methylamphetamine.
    Author: Paetsch PR, Baker GB, Caffaro LE, Greenshaw AJ, Rauw GA, Coutts RT.
    Journal: J Chromatogr; 1992 Jan 17; 573(2):313-7. PubMed ID: 1601966.
    Abstract:
    An electron-capture gas chromatographic procedure for the simultaneous determination of amphetamine and N-methylamphetamine in biological samples is described. The method employs extraction with the ion-pairing reagent bis(2-ethylhexyl)phosphoric acid, and back-extraction with 0.5 M hydrochloric acid. The hydrochloric acid phase is basified, and the amphetamines and the internal standard benzylamine are derivatized with pentafluorobenzenesulfonyl chloride prior to analysis on a gas chromatograph equipped with a capillary column. Levels of amphetamine and N-methylamphetamine have been determined in the urine and liver of rats treated chronically with (-)-deprenyl.
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