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  • Title: Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy.
    Author: Yie SM, Taylor RN, Librach C.
    Journal: Am J Obstet Gynecol; 2005 Jul; 193(1):204-8. PubMed ID: 16021080.
    Abstract:
    OBJECTIVE: The aim of this study was to determine whether circulating HLA-G levels, early in pregnancy, predict the subsequent development of preeclampsia (PE). STUDY DESIGN: Plasma samples, collected longitudinally during the first, second, and third trimesters, from 12 PE patients and 12 matched control patients were tested for HLA-G protein using a validated sandwich ELISA. RESULTS: First and second trimester HLA-G levels in PE were significantly lower than in control patients (first trimester, 1.25 microg/mL vs 1.95 microg/mL, P=.029; second trimester, 1.11 microg/mL vs 1.90 microg/mL, P=.024). CONCLUSION: Our results indicate that HLA-G levels in plasma from women who subsequently develop PE are lower than control patients, as early as the first trimester. This suggests that determination of circulating HLA-G protein concentration may be useful as an early predictor for the development of PE.
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