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  • Title: Ketotifen--a therapeutic agent of eosinophilic fasciitis?
    Author: Ching DW, Leibowitz MR.
    Journal: J Intern Med; 1992 May; 231(5):555-9. PubMed ID: 1602294.
    Abstract:
    A 30-year-old male with eosinophilic fasciitis (EF) associated with morphoea and vitiligo is described. The patient showed a partial response to prednisone, but did not respond to hydroxychloroquine, D-penicillamine and cimetidine. In the light of reports of increased plasma histamine levels, and a putative role of mast cells in the pathogenesis of EF, ketotifen (a mast cell stabilizer) was prescribed. This non-toxic drug has allowed the patient to continue hard physical labour without further relapses and without corticosteroid therapy.
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