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  • Title: [Markedly elevated serum neopterin levels in patients with hemophagocytic histiocytosis].
    Author: Shinmyozu K, Machigashira N, Itoyama T, Maruyama I, Osame M.
    Journal: Rinsho Ketsueki; 1992 Apr; 33(4):545-7. PubMed ID: 1602622.
    Abstract:
    The authors measured serum neopterin by HPLC in 3 patients with hemophagocytic histiocytosis (HH) with DIC which occurred during the clinical course of T cell malignant lymphoma (T-ML). Extremely high levels of serum neopterin (754.3 +/- SD 467.3 pmol/ml) were found in the patients, about 200, 13 and 10 times higher than that of normal subjects, non-HH DIC patients and non-HH/DIC T-ML patients. Moreover their serum soluble interleukin-2 receptor levels were markedly elevated. These results indicate that markedly raised serum neopterin would be a sensitive parameter for activation of the mononuclear phagocyte system closely associated with T-cell activation and may serve as a useful diagnostic marker for HH.
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