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  • Title: Role of nitrosative stress and poly(ADP-ribose) polymerase activation in myocardial reperfusion injury.
    Author: Szabó G, Bährle S.
    Journal: Curr Vasc Pharmacol; 2005 Jul; 3(3):215-20. PubMed ID: 16026318.
    Abstract:
    Ischemia and reperfusion injury leads to a complex pathophysiological process, which in turn results in the generation of free radicals. Peroxynitrite, a highly reactive species causes DNA single strand breaks, which activates the nuclear enzyme, poly (ADP-ribose) polymerase (PARP). The activation of PARP leads to an energy consuming inefficient repair cycle with subsequent depletion of NAD(+) and ATP pools and necrotic cell death. The present review overviews the pathophysiological role of the peroxynitrite-PARP pathway in cardiac ischemia/reperfusion injury with special reference to the therapeutic potential of PARP inhibitors in the treatment of this disease.
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