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  • Title: Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors.
    Author: Rodriguez-Pallares J, Guerra MJ, Labandeira-Garcia JL.
    Journal: Brain Res Dev Brain Res; 2005 Aug 08; 158(1-2):120-2. PubMed ID: 16026856.
    Abstract:
    Cultures of rat mesencephalic precursors treated with interleukin-1beta or angiotensin II contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with angiotensin II and interleukin-1beta did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.
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