These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity.
    Author: Münz C, Steinman RM, Fujii S.
    Journal: J Exp Med; 2005 Jul 18; 202(2):203-7. PubMed ID: 16027234.
    Abstract:
    Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes--natural killer (NK), natural killer T (NKT), and gammadelta T cells--also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.
    [Abstract] [Full Text] [Related] [New Search]