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  • Title: In vivo development of high-level fluoroquinolone resistance in Streptococcus pneumoniae in chronic obstructive pulmonary disease.
    Author: Pérez-Trallero E, Marimón JM, González A, Ercibengoa M, Larruskain J.
    Journal: Clin Infect Dis; 2005 Aug 15; 41(4):560-4. PubMed ID: 16028169.
    Abstract:
    Patients with chronic obstructive pulmonary disease are generally subjected to multiple regimens of antimicrobial treatment. The development of high-level levofloxacin resistance (i.e., a minimum inhibitory concentration >8 mu g/mL) in 8 patients whose previous pneumococcal isolates showed susceptibility is described. Molecular methods were used to characterize the strains and to study the sequential changes in fluoroquinolone targets.
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