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  • Title: Carcinogenicity of bracken fern (Pteridium esculentum) in New Zealand.
    Author: Smith BL, Embling PP, Agnew MP, Lauren DR, Holland PT.
    Journal: N Z Vet J; 1988 Jun; 36(2):56-8. PubMed ID: 16031441.
    Abstract:
    Bracken fern (Pteridium esculentum) was harvested from two sites LB and TB one of which (TB) was on a central North Island New Zealand farm where bovine enzootic haematuria (BEH) was known to occur. The fern was dried, ground and incorporated (25% w/w) into a pelleted diet and fed to female rats for a total of 162 days. Fifteen weeks later when the rats were autopsied it was found that numerous tumours, mainly of the ileum and urinary bladder were present in the animals fed the bracken fern from the TB site. Neoplasms were found in 85% of rats from the TB group compared with 11% in the LB group while only a single tumour (a haemangioma of the uterus) was observed in the controls. In all, there were neoplasms in 42, 5 and 1 organ/s from the TB, LB and control rat groups respectively (p<0.001). Analysis of the fern and pellets for ptaquiloside, the carcinogen in bracken fern, showed much higher levels present in the material from the TB site. There was 26 and 2270 microg ptaquiloside/g of dried fern and, for pellets from the same fern, 6.5 and 355 microg ptaquiloside/g of pellets, for one collection from the LB and TB sources respectively.
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