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  • Title: [Biochemical mechanisms of neurotoxic reactions to antibacterial preparations in patients with pulmonary tuberculosis].
    Author: Chelnokova NV, Starostenko EV, Salpagarov AM, Smirnova NA, Kruglova EG.
    Journal: Probl Tuberk; 1992; (1-2):8-10. PubMed ID: 1603797.
    Abstract:
    Examination comprising the electrophysiologic method and study of the biochemical parameters of the antioxidant/lipid peroxidation system and metabolism of biologic amines in 163 patients with infiltrative pulmonary tuberculosis has revealed a clear interaction existing between the functional changes of the CNS state, the state of antioxidative defense (alpha-tocopherol) and serotonin. This allows an assumption that the antioxidant/lipid peroxidation system and serotoninergic system actively participate in the pathogenesis of development of neurotoxic reactions to antibacterial preparations in the clinical picture of tuberculosis.
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