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  • Title: Synthesis and assay of isoquinoline derivatives as HIV-1 Tat-TAR interaction inhibitors.
    Author: He M, Yuan D, Lin W, Pang R, Yu X, Yang M.
    Journal: Bioorg Med Chem Lett; 2005 Sep 01; 15(17):3978-81. PubMed ID: 16039124.
    Abstract:
    Four new isoquinoline derivatives bearing guanidinium group or amino group-terminated side chain were synthesized to target the HIV-1 TAR element. Their abilities to bind TAR RNA and inhibit Tat-TAR RNA interaction were determined by CE analysis, a Tat-dependent HIV-1 LTR-driven CAT assay and SIV-induced syncytium evaluation.
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