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  • Title: Sustained release of 5-fluorouracil from oil/water emulsions.
    Author: Ishikawa M, Kikuta H, Imaizumi A, Suzuki E, Takayanagi Y, Sasaki K.
    Journal: Res Commun Chem Pathol Pharmacol; 1992 May; 76(2):245-8. PubMed ID: 1604048.
    Abstract:
    Release profile of 5-fluorouracil (5-FU) from O/W emulsion and bone marrow toxicity of 5-FU to mice were compared with those of an aqueous solution of 5-FU. 5-FU emulsion had lower bone marrow toxicity and a slower drug release rate than the 5-FU aqueous solution which exhibited high bone marrow toxicity and fast drug release rate. A correlation between the rate of drug release and bone marrow toxicity was suggested.
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