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  • Title: Early endotoxin tolerance in suckling rats.
    Author: Goto M, Yoshioka T, Young R, Gottschalk ME, Anderson CL, Zeller WP.
    Journal: Res Commun Chem Pathol Pharmacol; 1992 May; 76(2):249-52. PubMed ID: 1604049.
    Abstract:
    Early endotoxin tolerance has not been well investigated in the newborn. This study demonstrated that a sublethal dose of Salmonella enteritidis lipopolysaccharide (S. ent-LPS) or rough mutant Salmonella minnesota LPS (Re-LPS) induced early endotoxin tolerance in suckling rats, showing blunted hypoglycemia and decreased mortality. The mortality of endotoxic shock was lower in S. ent-LPS pretreated group than Re-LPS pretreated group. A sublethal dose of S. ent-LPS caused lactacidemia but Re-LPS did not. Therefore, early endotoxin tolerance appeared to be related to physiologic responses to the initial LPS exposure.
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