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  • Title: Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity.
    Author: Takashima J, Komiyama K, Ishiyama H, Kobayashi J, Ohsaki A.
    Journal: Planta Med; 2005 Jul; 71(7):654-8. PubMed ID: 16041652.
    Abstract:
    Four new flavonoids, brosimacutins J-M (1 - 4), were isolated from the bark of Brosimum acutifolium Huber together with a known flavan, brosimine A (5). The structures of compounds 1-4 were elucidated by spectroscopic means. 27 constituents of this plant including compounds 1-5 were evaluated for their cytotoxic activity against murine leukemia P388 cells. Although no compounds tested had any reversal effect on vincristine resistance, brocimacutins J-M (1-4) were cytotoxic to vincristine-resistant P388 cells (IC50 4.4 - 19 microg/mL).
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