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  • Title: Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis.
    Author: Jiménez A, Meckes M, Alvarez V, Torres J, Parra R.
    Journal: Phytother Res; 2005 Apr; 19(4):320-2. PubMed ID: 16041726.
    Abstract:
    Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, beta-sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99% at a concentration of 100 microg/mL.
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