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  • Title: An automated approach for analyzing D-periods in collagen fibril images.
    Author: Gkoumplias V, Zervakis M, Tzaphlidou M.
    Journal: IEEE Trans Biomed Eng; 2005 Jul; 52(7):1345-7. PubMed ID: 16041998.
    Abstract:
    This paper considers an approach for analyzing fibrillar collagen structures based on fundamental concepts of pattern recognition. It focuses on the quantitative comparison between collagen structural data (electron-optical data) and chemical data. Theoretical models in the form of sequence-generated histograms are used as reference for extracting and analyzing the structural unit in images from collagen fibrils. In this respect, collagen provides a valuable model system for studying the chemical basis of ultrastructure, as well as detecting the alterations in collagen fibril structure produced by a disorder. Application examples are presented and the results are compared with biochemical studies.
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