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  • Title: Development of cytochrome-c oxidase activity in rat heart: downregulation in newborn rats.
    Author: Drahota Z, Milerova M, Stieglerova A, Skarka L, Houstek J, Ostadal B.
    Journal: Cell Biochem Biophys; 2005; 43(1):87-94. PubMed ID: 16043886.
    Abstract:
    Cytochrome-c oxidase (COX) activity of the rat heart was two- to sevenfold activated when the membrane integrity was disrupted by hypotonic swelling, freezing-thawing, or a detergent, indicating that a large portion of COX capacity in intact mitochondria is not active. The effect of detergent was tested in heart mitochondria isolated from 1-, 5-, 15-, 29-, and 60-d-old rats; activation by detergent was up to 20-fold in 1-d-old animals, whereas in mitochondria from 60-d-old rats it was only 7-fold. Our data indicate that the rat heart exhibits significant developmental changes dependent on downregulation of COX activity in the neonatal period.
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