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  • Title: Synthesis of cell-penetrating peptides for cargo delivery.
    Author: Pooga M, Langel U.
    Journal: Methods Mol Biol; 2005; 298():77-89. PubMed ID: 16044541.
    Abstract:
    Cell-penetrating peptides (CPPs) have served as vehicles for the delivery of different molecules and particles into cells. The efficiency and noninvasive nature of peptide-mediated cellular transduction provides a promising tool for biomedical research. Studies of cell-penetrating constructs that deliver oligonucleotides, peptides, and proteins have elucidated several important cellular signaling mechanisms. Here we briefly describe the major classes of cell-penetrating peptides. We also present various strategies used to couple different cargoes to CPPs.
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