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  • Title: Fighting an enemy within: cytoplasmic inhibitors of bacterial cysteine proteases.
    Author: Potempa J, Golonka E, Filipek R, Shaw LN.
    Journal: Mol Microbiol; 2005 Aug; 57(3):605-10. PubMed ID: 16045606.
    Abstract:
    The genes encoding secreted, broad-spectrum activity cysteine proteases of Staphylococcus spp. (staphopains) and Streptococcus pyogenes (streptopain, SpeB) are genetically linked to genes encoding cytoplasmic inhibitors. While staphopain inhibitors have lipocalin-like folds, streptopain is inhibited by a protein bearing the scaffold of the enzyme profragment. Bioinformatic analysis of other prokaryotic genomes has revealed that two more species may utilize this same genetic arrangement to control streptopain-like proteases with lipocalin-like inhibitors, while three other species may employ a C-terminally located domain that resembles the profragment. This apparently represents a novel system that bacteria use to control the intracellular activity of their proteases.
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