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  • Title: Assessment of PINK1 (PARK6) polymorphisms in Finnish PD.
    Author: Clarimón J, Eerola J, Hellström O, Peuralinna T, Tienari PJ, Singleton AB.
    Journal: Neurobiol Aging; 2006 Jun; 27(6):906-7. PubMed ID: 16046032.
    Abstract:
    Recent data has demonstrated that mutations in PINK1, encoding PTEN-induced kinase 1, are a cause of early onset recessive parkinsonism (PARK6 locus). Common variability in genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). We analyzed whether six different genetic variants within and surrounding PINK1 contribute to the risk of sporadic PD in a Finnish case-control series. Our results indicate that this gene does not play a major role in the genetic predisposition to PD in this population.
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