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  • Title: Identification of vulnerable atherosclerotic plaque using IVUS-based thermal strain imaging.
    Author: Shi Y, Witte RS, O'Donnell M.
    Journal: IEEE Trans Ultrason Ferroelectr Freq Control; 2005 May; 52(5):844-50. PubMed ID: 16048186.
    Abstract:
    Pathology and autopsy studies have demonstrated that sudden disruption of vulnerable atherosclerotic plaque is responsible for most acute coronary syndromes. These plaques are characterized by a lipid-rich core with abundant inflammatory cells and a thin fibrous cap. Thermal strain imaging (TSI) using intravascular ultrasound (IVUS) has been proposed for high-risk arterial plaque detection, in which image contrast results from the temperature dependence of sound speed. It has the potential to distinguish a lipid-laden lesion from the arterial vascular wall due to its strong contrast between water-bearing and lipid-bearing tissue. Initial simulations indicate plaque identification is possible for a 1 degrees C temperature rise. A phantom experiment using an IVUS imaging array further supports the concept, and results agree reasonably well with prediction.
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