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  • Title: Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature.
    Author: Delacruz V, Jorda M, Gomez-Fernandez C, Benedetto P, Ganjei P.
    Journal: Arch Pathol Lab Med; 2005 Aug; 129(8):1054-6. PubMed ID: 16048401.
    Abstract:
    Primary angiosarcoma of the spleen is a very rare neoplasm with a poor prognosis. The definitive diagnosis is usually based on the histologic evaluation of the splenectomy specimen. We describe a case of angiosarcoma diagnosed by fine-needle aspiration cytology prior to splenectomy. A 69-year-old white woman presented with heterogeneous lesions in the spleen during a follow-up computed tomographic scan for a history of liposarcoma of the right buttock. A malignant endothelial neoplasm was diagnosed by fine-needle aspiration cytology using immunocytochemistry, and a splenectomy confirmed the presence of angiosarcoma. To our knowledge, this is the first well-documented and confirmed case of primary angiosarcoma of the spleen diagnosed by fine-needle aspiration cytology. This report emphasizes the value of fine-needle aspiration cytology as an important diagnostic tool in splenic neoplasms.
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