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  • Title: TAK-220, a novel small-molecule CCR5 antagonist, has favorable anti-human immunodeficiency virus interactions with other antiretrovirals in vitro.
    Author: Tremblay CL, Giguel F, Guan Y, Chou TC, Takashima K, Hirsch MS.
    Journal: Antimicrob Agents Chemother; 2005 Aug; 49(8):3483-5. PubMed ID: 16048964.
    Abstract:
    TAK-220 is a CCR5 antagonist, part of the new class of anti-human immunodeficiency virus type 1 (anti-HIV-1) entry inhibitors. We evaluated the anti-HIV-1 interactions between TAK-220 and various antiretrovirals in vitro. Synergy was observed with all drugs at the 90 and 95% inhibitory concentrations. The favorable drug interactions observed suggest that further clinical evaluation is warranted.
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