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  • Title: Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus.
    Author: Nagura J, Kijima K, Kurazono M, Takahata S, Sugano T, Tanaka Y, Hirai Y, Yamada K, Takayama Y, Shitara E, Yonezawa M.
    Journal: Antimicrob Agents Chemother; 2005 Aug; 49(8):3526-8. PubMed ID: 16048975.
    Abstract:
    The efficacy of ME1036, a novel parenteral carbapenem, was compared with that of vancomycin by using a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. Compared with vancomycin, ME1036 reduced the bacterial counts in the vegetations at a lower dosage or over a shorter period of administration when it was used for the treatment of MRSA endocarditis.
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